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John's wort and Goldenseal, have such a high risk of interactions, that many experts recommend avoiding them entirely if you take any prescriptions

These metabolites exert biologically relevant effects of their own and have greater bioavailability than their parent polyphenolic compounds (20), representing a likely mediator of polyphenols effect on health outcomes, including on sleep health

1 2 Rachmany L, Tweedie D, Li Y, Rubovitch V, Holloway HW, Miller J, Hoffer BJ, Greig NH, Pick CG (October 2013)

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Plan Ahead: Have a clear calculation of your desired final concentration before starting