Although the relationship between GLP-1RAs and thyroid cancer risk remains uncertain, caution is advised when prescribing GLP-1RAs in individuals with a history of thyroid cancer or in those with higher risk [24]
Advertisement While semaglutide works to mimic GLP-1 hormones, tirzepatide (like Mounjaro and Zepbound) is considered a dual agonist
They enhance regulatory T-cell function, which is significant because defective T-cell regulation is a core driver of autoimmune thyroid destruction
In a 12-week human trial, participants achieved on average
GLP-1 RAs exert direct and indirect effects on the CV system including vasodilation, natriuresis anti-atherosclerotic effects, improvements in endothelial function, anti-inflammatory effects (decrease cytokines level such as tumor necrosis factor, interlukin-1, interlukin-6) and a consequent decrease in C-reactive protein, and reductions in infarct size (60, 84, 85)