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Over the past decade, GWAS and whole-exome sequencing have uncovered numerous potential blood pressure-related pathways, however consistent associations with hypertension remain uncommon or rare [12, 13]

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However, nearly half of the IBD-associated loci have also been linked to other immune-mediated conditions, such as psoriasis and ankylosing spondylitis [19, 23]

The -glutamyl amino acid can be transported back into the cell where -glutamyl cyclo-transferase (GCT) releases the acceptor amino acid to form 5-oxo-proline, the latter of which is converted back to glutamate by oxo-prolinase and used for GSH synthesis

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