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196 In the tumor environment, succinate could be produced and released by tumor cells, and via interacting with succinate receptor 1 to activate phosphoinositide-3-kinase/protein kinase B pathway and upregulate HIF-1, inducing macrophage polarization, and enhancing tumor cell metastasis

Metabolomics (2018) 14(6):85

The compound's oral bioavailability and long plasma half-life (approximately 6 hours, with GH effects persisting 24 hours) distinguish it from injectable GH secretagogues like GHRP-6 2

10.1126/science.aba3656 14 BucciK.BayoumiM.StevackK.Watson-LeungT.RochmanC

doi: 10.1111/j.1528-1167.2007.01185.x 373 ScorzaFAAridaRMNaffah-MazzacorattiMScerniDACalderazzoLCavalheiroEA