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Exerc 2010;42:180918 Fallah F, Mahdavi R (2023) Ameliorating effects of L-carnitine and synbiotic co- supplementation on anthropometric measures and cardiometabolic traits in women with obesity: a randomized controlled clinical trial

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Indeed, the selection of patients who can benefit from this therapy is a very important consideration

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Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported