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In vitro studies have also demonstrated that Schisandrin B exerts anti-inflammatory effects by modulating redox-sensitive transcription factors, such as Nrf2 and NF-B ( 4.2.2 Antioxidant effects Reactive oxygen species (ROS), when excessively accumulated in hepatocytes, cause oxidative stress, leading to DNA damage, protein oxidation, and lipid peroxidation (Zheng et al., 2019)