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The exact mechanisms of pMPM1 suppression by RSL3 remains to be uncovered

In obese murine models, GLP-1 receptor activation has been demonstrated to reduce macrophage infiltration into adipose tissue and to suppress inflammatory signaling (Nuclear factor-B (NF-B), jun N-terminal kinase (JNK)) in both adipocytes and adipose tissue macrophages (ATM), changes that were associated with improved insulin sensitivity [12]

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We did not adjust this model for data that did not meet tests for normality, as mixed linear models are generally robust to violations of this assumption (Knief and Forstmeier, 2021)