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Third, a substantial proportion of the supporting evidence is derived from experimental and animal studies, with limited direct confirmation in well-characterized human cohorts of lean older adults with diabetes

As uric acid builds around joints like the ankles and knees, it can clump together to form bigger crystals, leading to intense pain and pressure

Both RickA and Sca2 contribute to cell-to-cell spread, however Sca2-based motility is the major mediator of cell-to-cell spread 34,35,36,37,64

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