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Gallbladder complications including cholelithiasis (gallstone formation) have emerged as a dose-related risk, particularly with rapid weight loss exceeding 1.5 pounds weekly

Lancet 2021;398:181124.PubMed 35

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Cardiovascular outcomes associated with SGLT-2 inhibitors versus other glucose-lowering drugs in patients with type 2 diabetes: A real-world systematic review and meta-analysis