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CoQ 10 H 2 regulates calcium signaling pathways by promoting expression and function of SERCA2 As the most classical pathway in the Mitogen-activated protein kinase (MAPK) system, the extracellular signal-regulated kinase 1 and 2 (ERK1/2) pathway transports extracellular signals into the nucleus to activate various effector molecules and regulate biological activities such as cell proliferation and apoptosis via a series of cascade transduction systems 53

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