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Dihexa exerted spine induction effects at sub-nano-molar concentrations with some spine formation by Dihexa and Nlel -AnglV occurring as early as 30 minutes after stimulation (Figure 3D)

Phase 3 REDEFINE trials enrolled over 3,400 participants with 68-week follow-up

Enhanced Protocol: REDEFINE Clinical Titration The clinical trial program uses a structured 16-week titration to the full therapeutic dose: This clinical protocol is the evidence-based approach used in REDEFINE trials

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