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Sep 19 2023;14(18):8533-8544

The particles were extracted on a binned dataset with a pixel size of 2.142 and were subjected to reference-free 2D classification, producing 4,334,371 particles with well-defined averages

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Signaling pathways involved in regulating MMPs transcription mainly include mitogen-activated protein kinase (MAPK), 101,109,110 reactive oxygen species (ROS), 111 adenosine 5-monophosphate-activated protein kinase (AMPK), 112,113 extracellular-signal-regulated kinase (ERK), 114 JUN N-terminal kinase (JNK) etc