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They were subsequently randomly allocated into five groups, receiving different treatment regimen including: (I) PBS, (II) Mn/TI@mHSA, (III) P-Mn@mHSA, (IV) P-Mn/TI@mHSA-N, and (V) P-Mn/TI@mHSA, combined with a high-fat diet for an additional month

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This phenomenon may be attributed to the fact that larger individuals undergo a more pronounced redistribution of body fluids within their internal organs in microgravity, resulting in significant fluid shifts between the abdominal and thoracic compartments

This participant subsequently withdrew but completed the scheduled follow-up visit, including all safety assessments