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Description

This result could be explained by the fact that catabolism of proline in the gdh3 / gdh3 mutant involves only NAD + -dependent reactions, including the Gdh2- and Put2-catalysed reactions

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By inhibiting the release of NAD(P)H, an oxidative product of glutamate, NADH can bind to the NADH/ADP binding site and strengthen the inhibitory effect of GTP on GDH activity

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