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Who Should Not Take Retatrutide Based on who was excluded from clinical trials and general safety concerns, Retatrutide may not be suitable for: People with a personal or family history of a specific type of thyroid cancer called medullary thyroid carcinoma (MTC) People with a rare condition called Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) People who have had severe inflammation of the pancreas (pancreatitis) Women who are pregnant or breastfeeding People with serious digestive or stomach conditions Always consult your healthcare provider before starting any new medication