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In a randomized, double-blind, placebo-controlled trial, tesamorelin reduced liver fat and was associated with less fibrosis progression, and a targeted proteomic and transcriptomic analysis of that trial showed the drug lowered fibro-inflammatory mediators including VEGFA, TGF-1, and CSF1
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For example, a meta-analysis of 31 randomized, controlled trials reports that the most common side effects observed in the hGH studies and their respective incidences were [16]: Soft tissue edema: 50% Insulin resistance: 22% Arthralgias: 21% Carpal tunnel syndrome: 19% These side effects are transient and usually subside as the patient gets used to the therapy
Nakhostin-Roohi, Asian J
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