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Whether H2O2 has a direct effect on MAPK or activates upstream effectors is unclear (Hancock et al., 2001)

Two other studies 34, 35 have observed that H 2 O 2 may reduce the release of some neurotransmitters through activation of ATP-sensitive K-channels, the mechanism that has been suggested to underlie the beneficial effects of H 2 O 2 during metabolic stress

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