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In patients taking opioids for an extended period of time at high doses, ensure that a multimodal approach to pain management, including mental health support (if needed), is in place prior to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION, WARNINGS]

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For example, evidence suggests that sulforaphane, a bioactive compound derived from broccoli and broccoli sprouts, increases glutathione in the brain

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