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Using Catalase to clear H 2 O 2 prevented the stretch-induced translocation of Notch3 to the nucleus and decreased the Notch3 extracellular domain (197)

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For instance, in a six-month randomized controlled trial of 72 patients with Friedreichs ataxia (a neurodegenerative disorder characterized by mitochondrial iron accumulation), 20 mg/kg/day DFP was well tolerated but higher doses (40 and 60 mg/kg/day) were associated with increased adverse events and worsening of ataxia symptoms (Pandolfo et al., 2014)

A randomized double-blind placebo controlled phase I-II study on clinical and molecular effects of dietary supplements in men with precancerous prostatic lesions