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TS inhibition by 5FU regulates mitochondrial biogenesis through mTORPGC1 signalling 5FU has a multimodal mechanism of action: promoting DNA damage directly via its metabolite FdUTP or by inhibition of TS via FdUMP, depleting the pool of thymidine available for DNA synthesis, and causing RNA damage via FUTP (Fig

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The remaining five mice were sacrificed at postoperative day 4

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When it assembles, it triggers a cytokine storm, a cascade of inflammatory signals that recruit more immune cells and perpetuate the cycle