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Effect of a 12-mo micronutrient intervention on learning and memory in well-nourished and marginally nourished school-aged children: 2 parallel, randomized, placebo-controlled studies in Australia and Indonesia

The problem is in the gut, so delivering the compound directly to the gut lining is the most logical and effective approach

Most available studies are underpowered, short-term, and heterogeneous in design, making it difficult to draw firm conclusions about long-term efficacy, optimal dosing strategies, or the specific patient subgroups most likely to benefit

This raises an intriguing question of whether alternative sources of energy, such as ketone bodies by-passing the glycolytic pathway, might lead to increases in energy, and indeed some studies showed a reduction in fatigue in ME/CFS on a ketone diet [80]

doi: 10.3390/ijerph17249379 57