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In practical terms, both compounds currently sit in a transitional regulatory status: no longer explicitly restricted, but not yet authorized for routine compounding either

Mianserin, a tetracyclic antidepressant, has been shown to inhibit tumor growth in SW480 cells in vitro and in vivo through ASCT2 inhibition (Duan et al., 2022)

10.1016/j.exger.2024.112522 38 YingY.TangQ.YangJ.GuiS.ZhangY.ShenY.et al (2024)

Topical tretinoin remains the most evidence-supported anti-aging molecule we have, full stop