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In addition, in the pathogenesis of GERD, the abnormalities of digestive tract dynamics have gradually been emphasized by researchers, and it has been further found that the brain-gut peptide (neurotransmitter) in the brain-gut axis is not only related to visceral hypersensitivity, but also plays an important role in regulating gastrointestinal dynamics, and changes in the bacterial microbiome and its structure can stimulate the secretion of brain-gut peptide, so the emphasis on the bacterial microbiome in the future research will also provide therapeutic opportunities for the treatment of GERD

Obesity also increases risk for urinary tract disease, arthritis, skin conditions, and anesthetic complications

@leung_cyp2e1_2013 This indicates that CYP4A induction could be an alternative pathway when CYP2E1 is less available [28]

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