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Buse, Professor of Medicine at the University of North Carolina School of Medicine and co-chair of the SOUL steering committee, emphasized that even in the absence of a previous heart attack or stroke, adults with type 2 diabetes face an increased risk of cardiovascular events, underscoring the need for therapies that go beyond managing blood sugar. He added that having an oral GLP-1 therapy to help improve glycemic control was an innovation in and of itself

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Semaglutide is generally easier to tolerate in the early weeks, which is one reason some doctors prefer it as a starting point for people who are sensitive to digestive side effects

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Makker K, Agarwal A, Sharma R (2009) Oxidative stress & male infertility