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doi: 10.1093/humrep/dei358 69 BakhshalizadehSHockDHSiddallNAKlineBLSreenivasanRBellKMet al

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2.2 Metabolic remodeling The occurrence and progression of PH are closely associated with multi-cellular metabolic reprogramming, which collectively drives the pathological process of the disease through abnormal switching of cellular energy metabolic pathways, regulation of key metabolites and signaling pathways, and bidirectional interactions between metabolic disorders and vascular remodeling (Figure 2)

Recent in vivo and in vitro investigations have shown that LC can mitigate oxidative damage in models of cardiovascular disease by diminishing lipid peroxidation, scavenging reactive oxygen species such as hydrogen peroxide and superoxide, chelating metal ions involved in oxidative stress (Brodericksq et al