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The rapid growth of glucagon-like peptide-1 receptor agonists (GLP-1RA) for the treatment of obesity has drawn public attention to treatments for cardiometabolic diseases

Leptin levels decrease during weight loss due to reduced fat mass, which promotes increased food consumption and decreased energy expenditure

Studies suggest that up to 25 to 40% of weight loss from pharmacotherapy alone can be lean mass rather than fat

SL was responsible for the supervision, project administration, formal analysis, data curation, validation, review, and editing of the final manuscript

Long-term follow-up to week 104 in the S-LiTE trial demonstrated differing legacy effects