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Inclusion criteria were 1) patients aged 18 yr taking a GLP-1 RA for diabetes mellitus and/or weight loss, 2) gastric emptying assessment reported as emptying T , and 3) study design that was a randomized controlled trial or a prospective cohort study

Research suggests that individuals who continue this combination after initial weight loss can sustain a 70% success rate in maintaining their weight

As gastric emptying normalizes and appetite-suppressing signals fade, patients commonly experience reduced fullness and increased appetite as the medication's effects wane

Finally, the anticipated PK changes due to delayed gastric emptying depend on whether solubility or permeability is the overall rate-limiting step in absorption

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