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The difference is the delivery method and the fact that oral administration requires a higher dose. Since the pill has to pass through the digestive system, its given at a greater concentration than the injection to achieve similar effectiveness

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Research has shown that metformin can block the reabsorption of bile acids by reducing the levels of Na + -dependent bile acid transporter proteins and controlling the function of farnesoid X receptor (FXR) (Lien et al., 2014