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H., Stagge, A., & Smith, U

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Cejuela et al., 2022)

They found that long-term beta blocker administration decreased endogenous melatonin production by 50%, and in these patients taking the beta blockers, there was a significant increase in sleep latency (the time it takes for a person to fall asleep after lying down in bed and attempting to sleep) and decreased REM sleep (REM sleep is characterized by rapid movement of the eyes, vivid dreaming, and heightened brain activity)

An analysis of variance taking age into consideration did not change the TIMP-1 finding ( p = 0.463)