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Although 5% weight loss did not show a net benefit, Moll and colleagues noted that it could be net beneficial for some individuals, depending on their willingness to accept the harm outcomes. For example, one of the harm outcomes that highly influenced the unfavorable benefit-harm balance of tirzepatide was alopecia, they explained

The FDA or NIH should also conduct post-market surveillance of patients taking compounded GLP-1 drugs and compare their outcomes to those of patients taking brand-name products

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It is a non-hormonal approach: no IGF-1 or cortisol changes, no stimulant jitters, no appetite suppression