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However, independent lines of evidence continue to support involvement of FNDC5/irisin signaling in metabolic adaptation, bone remodeling, and neuroprotection, suggesting that early technical limitations may have obscured rather than invalidated its physiological relevance ( A key limitation for irisin translation remains the absence of a definitively identified receptor

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Multidisciplinary utilization of dimethyl sulfoxide: Pharmacological, cellular, and molecular aspects

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