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Z., Banigan, E

They mapped its amino acid sequence, confirmed its role in stimulating insulin after meals, and found it degraded quickly, spurring the search for longer-lasting synthetic versions

The drier areas need a bit more encouragement

Indeed, generating a fusion or conjugation between a peptide and a carrier molecule such as an antibody Fc fragment 23,24 or a full antibody 25,26 is a well described half-life extension strategy to address their rapid clearance from circulation and improve their therapeutic potential

Although demographic and clinical predictors of discontinuation have been assessed, 74 the underlying reasons for discontinuation remain poorly quantified