doi:10.1111/eci.13454 Ma Y, He FJ, Sun Q, et al
30 It outperformed dulaglutide 1.5 mg/day at the highest doses, albeit in a small group of study participants
No two words can send a shiver down the spine of a beauty enthusiast like the purge. No, not the dystopian horror film although some might say the skin care version of purging is just as heart-stoppingly scary
However, important limitations exist in the current evidence: Most studies have been relatively small with short follow-up periods Many participants had concurrent obesity, making it difficult to separate weight loss effects from direct effects on binge eating behaviour Long-term efficacy and safety data specifically for binge eating disorder are lacking The psychological and behavioural components of BED may require interventions beyond pharmacological appetite suppression There is no official link established by regulatory bodies between GLP-1 agonists and binge eating disorder treatment
In addition, both riboflavin and PLP are essential determinants of the kynurenine pathway which influence glutamate receptors, hence, glutamate excitotoxicity potential, as shown in Section Riboflavin as a Determinant of the Kynurenine Pathway. Concerning PD, glutamate excitotoxicity contributes to dopaminergic neuronal loss (84)
