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Transdermal delivery of GLP-1 medications faces significant challenges due to the large molecular size of GLP-1 analogs and the skin's natural barrier function

Despite these promising results, the researchers said this study drew people from a small geographic region from within a single health system and its participants were predominantly white, which could limit the ability to translate these findings to other geographies or ethnic groups

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To help fill this gap, the researchers looked back at hundreds of singleton pregnancies delivered in the Mass General Brigham health system between 2016 and 2025

Systemic exposure varies widely