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The signs that matter clinically are carpal-tunnel-like wrist symptoms, persistent joint pain, or elevated blood glucose, these usually indicate IGF-1 is too high and dosing needs to be reduced

Chronic stimulation appears to gradually desensitize the HPA axis, impairing in particular its anti-inflammatory function, so that the body becomes unable to respond properly to new stressors

Also studied for appetite suppression and enhanced sexual stimulus at higher doses

The conversation around potential risks isn't complete without considering the lack of extensive human clinical trials