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Conclusions and Lessons Learned The potential of DPP-4 inhibition as a glucose-lowering concept has now been explored for more than 25 years and it is more than 10 years since several DPP-4 inhibitors were introduced to the market (Figure 1)

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Tertiary structure validation Procheck Ramachandran Plot v.3.5.4 67 and ERRAT 68 of the SAVES V6.0 web tool and ProSA-Web 69 were used for structural evaluation and stereochemical analyses