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In the H 2 O 2 -induced melanocyte model, Hyp protected melanocytes from oxidative damage by regulating the PI3K/Akt pathway, inhibiting p38 phosphorylation and suppressing mitochondrial apoptotic signaling, which included upregulation of the Bcl-2/Bax ratio and expression of Akt, and downregulation of caspase 3, p38 (Yang et al., 2016)

Lupeol, an androgen receptor inhibitor, enhances the chemosensitivity of prostate cancer stem cells to antiandrogen enzalutamide-based therapy

In this work, small molecule fragments obtained by X-ray crystallography are ligated and partially optimized as non-covalent, and orally bioavailable inhibitors of TGR

For those in Mumbai, Ambrosia Aesthetics , led by Dr