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Whether GLP-1RAs exert direct modulation of the hypothalamic-pituitary-ovarian (HPO) axis beyond these metabolic pathways remains to be verified by clinical mechanistic evidence

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The study showed a safety and tolerability profile consistent with the GLP-1RA class, along with clinically meaningful weight reduction and improvements in HbA1c among participants treated with elecoglipron

MH, JW, and DL performed statistical analyses