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Food for thought: nutrient metabolism controlling early T cell development

Mitochondrial engagement, including binding to voltage-dependent anion channels, can heighten oxidative stress in nonlesional tissues and contribute to organ dysfunction independent of lesion-directed ferroptosis (94, 95)

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Baseline cohort definitions include demographic characteristics (e.g., age, sex, race/ethnicity, diabetes duration, smoking rate), relevant biomarkers (e.g., HbA1c, systolic and diastolic blood pressure, total cholesterol, low- and high-density lipoprotein, triglycerides, BMI, heart rate, white blood cell count, and estimated glomerular filtration rate), and history of micro- and macrovascular complications (e.g., eye disease, diseases of the lower extremities, kidney disease, heart disease, heart attack, heart failure, and stroke)