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In summary, metformin may affect EC through the modulation of glycolysis, lipogenesis, and protein synthesis, as well as inhibition of tumor cell growth and proliferation, and promotion of apoptosis

Lin Y-K, Liang C-H, Lin Y-H, Lin T-W, Vazquez JJ, van Campen A, et al

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The reduced cell number in G6PDH-deficient growth plates is thus caused by increased cell death and not by impaired proliferation

By helping control blood glucose, metformin reduces the risk of diabetes-related complications and supports long-term health