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Incubation of NFT with cell or tissue homogenates, microsomal preparations, or isolated mitochondria revealed one-electron reduction of NFT to yield an NFT radical anion ( NFT ) by flavoprotein-reductases such as xanthine oxidase, aldehyde dehydrogenase, thioredoxin reductase, cytochrome b 5 reductase, and cytochrome P450 reductase (CYPOR) (Miller et al
Vitamin C supports the overall health of those cells and reduces fatigue-inducing oxidative stress
Parallel experiments using the ferroptosis inhibitor liproxstatin-1 show similar protective effects, suggesting that ferroptosis plays a causal role in psoriatic inflammation
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