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The landscape of heart failure (HF) management is evolving alongside a deeper understanding of how metabolic dysfunction drives cardiac pathology and the progression of HF, particularly in phenotypes like HF with preserved ejection fraction (HFpEF) associated with obesity

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Vitamin B6 (pyridoxine) at doses of 1025 mg three times daily has demonstrated anti-nausea effects and is generally well-tolerated, though patients should not exceed 100 mg daily due to risk of peripheral neuropathy with long-term high doses