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However, the structures of isocereulides E ( 6 ) and F ( 7 ), as well as isocereulide G ( 8 ), which shows another constitutional arrangement of the depsidipeptides D- O -Leu-D-Ala and L- O -Val-L-Val when compared to the isobaric cereulide, violate the canonical NRPS biosynthesis logic as suggested for cereulide production
Descriptively, degree of clinical improvement achieved by the patient group in the above study (Yao et al., 2012) represented an increase from Unable to function in almost all areas at baseline to Major impairment in several areas 1 month later (Global Assessment Scale or GAS anchor points)
The most common side effects include nausea, headaches, skin flushing, itching, and unusual fatigue
The available evidence is preclinically solid but limited in human medicine to a single field of application
