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Core symptoms span intrusive memories, hyperarousal, avoidance and negative shifts in mood and cognition (Petakh et al., 2024), yet clinical presentation is highly heterogeneousshaped by trauma type and individual neurobiology (Huckins et al., 2020)

For instance, Dersu Ozdemir and colleagues reported that natural withdrawal from opioids, such as morphine and fentanyl, can induce significant anxiety and depression-like behaviors [3,4]

A quantum chemical study of the reactivity of acetaminophen (paracetamol) toxic metabolite N-acetyl-p-benzoquinone imine with deoxyguanosine and glutathione

The risk of fragility fractures in new users of dipeptidyl peptidase-4 inhibitors compared to sulfonylureas and other anti-diabetic drugs: a cohort study

Mechanistically, GLP-1s are thought to cross the blood-brain barrier and act directly on the brain, potentially reducing neuroinflammation, improving insulin signaling, and altering amyloid and tau pathology