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Unlike semaglutide, which targets only GLP-1 receptors, tirzepatide is a dual agonist it activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors simultaneously

Gonadotrophin deficiency due to mass effects of pituitary adenomas or gonadotrophin suppression due to cortisol or prolactin excess might induce insulin resistance in men and women that can be improved by hormone replacement therapy

The Promising Side: Potential Mental Health Benefits The presence of GLP-1 receptors in the brain has implications for mental health

Only pre-filled injection pens (Mounjaro and Zepbound) manufactured by Eli Lilly are approved, as compounded or reconstituted powder forms carry risks of contamination, dosing errors, and unknown ingredient stability

Rybelsus (oral semaglutide) was approved in the U.S