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GLP-1 regulates brain areas that modulate food reward with particular physiological relevance in controlling feeding behavior [47]

Compared to popular GLP-1RAs like semaglutide, orforglipron does not require injection or an absorption enhancer with fasting to achieve exposure, and it can be taken without water or food restrictions, according to Phase 1 pharmacokinetic data

Gastrointestinal disorders were the most commonly reported adverse events (163 [34%] in the 20 mg group and 148 [31%] in the 10 mg group)

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Expression, physiological action, and coexpression patterns of neuropeptide Y in rat taste-bud cells