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4 OA is a multifactorial disorder and its pathogenesis is influenced by several intrinsic and extrinsic factors which may activate signaling of molecular pathways associated with articular injury

doi: 10.3389/fonc.2024.1329133 Received 28 October 2023 Accepted 23 January 2024 Published 07 February 2024 Volume 14 - 2024 Edited by Mignon Van Gent, Amsterdam University Medical Center, Netherlands Reviewed by Federica Perelli, Azienda USL Toscana Centro, Italy Wuliang Wang, Second Affiliated Hospital of Zhengzhou University, China Updates Copyright 2024 Chen, Zhao, Yang and Xu

The National Center for Complementary and Integrative Health (NCCIH) also conducts and supports research on these approaches

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Overall, the regulation of autophagy by TXNIP exhibits a dual nature, capable of either suppressing or promoting autophagy