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It immediately increased to a higher level until 4 h pi and then decreased to a minimum at 12 h pi , before slowly recovering

10.1016/j.cmet.2020.10.011 193 ZhengL.ZhangZ.ShengP.MobasheriA

Many patients eventually reduce their dose, switch to maintenance-level dosing, or transition off the medication entirely

If the plasma level is in the high-risk region of the nomogram, the risk of developing hepatotoxicity is 60% or higher, and antidote therapy is warranted

Nude oocytes were separated from the COCs by repeated blowing-and-suction with a mouth glass pipette (~160 m in diameter) in MEM (minimum essential medium) + medium (0.01 mM EDTA, 0.23 mM Na-pyruvate, 0.2 mM penicillin/streptomycin, and 3 mg/ml BSA in MEM