is glp 1 retatrutide triple agonist gip glp-1 glucagon receptor Agonism Based Therapies for Obesity Retatrutide 10mg & 20mg Research

SkinnyRx wins on the only oral tirzepatide tablets in this comparison

Cohen's d = 0.65

There is a boxed warning in prescribing information for the GLP-1 drug class regarding thyroid C-cell tumors observed in animal studies - this has led to GLP-1 medications being contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2

Clinical studies have demonstrated its effectiveness in obesity treatment, showing significant reductions in body weight, BMI, waist and hip circumference, and body fat, outperforming placebos and setting new standards for weight loss therapies

the FDA greenlit them to treat type 2 diabetes in 2017 and 2022, respectively