The GLP-1 receptor (GLP-1R) is an established drug target for the treatment of diabetes and obesity 2 , whereas the therapeutic potential of the GIP receptor (GIPR) is a subject of debate
GLP-1RAs maintain vascular health GLP-1 plays crucial role in proper functioning of vascular endothelium, and is linked to improved endothelial function, and enhanced nitric oxide synthase-driven vasodilation [22]
A randomized Phase I study of the safety, tolerability, pharmacokinetics and pharmacodynamics of BI 456906, a dual glucagon receptor/glucagon-like peptide-1 receptor agonist, in healthy Japanese men with overweight/obesity
Wow, this could be a game changer, especially with brain-related inflammatory diseases
10.1093/cvr/cvt036 243 PernowJ.KissA.TratsiakovichY.ClimentB